Abstract
Opioid use disorder (OUD) is characterized by a problematic pattern of opioid use leading to clinically-significant impairment or distress. Opioid agonist treatment is an [...]
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Recent research suggests that early onset of intoxication (EOI) may be of greater importance for a wide range of subsequent adverse outcomes than early drinking experiences [...]
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Impulsivity is a multidimensional construct that plays a prominent role in the development, maintenance, and relapse of addictive disorders. The UPPS-P model of impulsivity, [...]
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While addictions to substances such as alcohol, tobacco, and other drugs have been extensively investigated, interest has been growing in potential non-substance-related addictive [...]
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The pronounced discrepancy between smokers' intentions to quit and their smoking behavior has led researchers to suggest that many smokers are time inconsistent, have self-control [...]
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The construct of craving has been shown to play a crucial role in the development and maintenance of addictive behaviors. Both novelty seeking and desire thinking have been [...]
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The current study examined the moderating effects of smoking amount per day on the relation between anxiety sensitivity and nicotine dependence, cigarette smoking outcome [...]
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Introduction: The main aim of this study is to improve our knowledge on binge drinking behavior in adolescents. In particular, we tested a model of predictors of binge drinking [...]
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Men and women differ in their patterns of help-seeking for health and social problems. For people experiencing problem gambling, feelings of stigma may affect if and when [...]
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Heavy drinking is a considerable public health concern. There is a broad evidence-base examining the separate contributions of personality characteristics, motives and alcohol-expectancies [...]
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To examine whether a group of social drinkers showed longer response latencies to alcohol-related stimuli than neutral stimuli and to test whether exposure to 1) an alcohol-related [...]
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Alcohol use is responsible for a high level of mortality and morbidity throughout the world. The WHO global strategy recommends that the detrimental effects of alcohol use [...]
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A numerical study of unidimensional and steady state bimodal flux diffusion equation has been developed using the Finite Volume Method. In addition, with the Ficks flux, this [...]
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This is the second of two complementary articles that deal with the implementation of an automatic calibration routine coupled to a simulation model of runoff and hydraulic [...]
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This is the first of two complementary articles that deal with the implementation of an automatic calibration routine coupled to a simulation model of runoff and the flow [...]
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This paper presents a study on the structural hot spot stress method and the master curve method (Battelle) for evaluating the fatigue life of a T‐shaped welded joint. Both [...]
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This paper describes a procedure based on the concept of Equivalent Distributed Loads (EDL) applied to the Finite Elements Method (FEM) based on displacements and exact nodal [...]
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In the copper sulfides smelting process, the Teniente-type converter generates highly corrosive and toxic gases, which is why treating them is crucial in order to avoid environmental [...]
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The cardiovascular diseases constitute one of the main causes of death worldwide. One of the main diseases is atherosclerosis, which causes narrowing of the arterial lumen. [...]
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In the FCC process two configurations riser are numerically analyzed varying the upper outlet orientation using a 2 D CFD model which includes the Two Fluid Model (TFM), Kinetic [...]
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This paper presents the application of stabilized mixed explicit strain/displacement formulation (MEX-FEM) [23, 24] for solving non-linear plasticity problems in solid mechanics [...]
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The present work shows the application of a change point model (CPM) algorithm, based on non-parametric tests, to turbulent structures detection in an airflow. It seeks to [...]
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This paper focuses on estimating the modal parameters of the dynamic system that constitutes the pedestrian footbridge of the Science Museum of the city of Valladolid (Spain). [...]
Abstract
信号分子在生命过程中起着重要作用,它的传输通路对调节生理功能和病理的发展具有决定性作用。但是我们对这些通路的认识仍不全面。中医用阴阳五行来描述人体内的生理过程,但至今还没找到科学依据支持中医理论。黄帝内经认为心肝脾肺肾(五行)各有其阳阴气,并指出了每个“行”的生理功能和五行之间的相互关系。我们用迭代筛选法,将信号分子与黄帝内经所列各“行”的生理功能和相互关系一一比较,找出了五行中阳阴气与信号分子之间的直接映射,而满足这些关系的概率大概为十万分之二到百万分之一。这使我们发现阴阳五行实际上描述了人体中信号分子的传输通路,中草药的功用是调节各个信号分子。通过这一映射关系,可以清楚地看到现代医学和中医对一些疾病,如血尿、 [...]
Abstract
In our previous in vitro study mid-myocardial relative to epicardial pacing decreased transmural dispersion of depolarization (TDR) and prevented ventricular arrhythmia. We [...]
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We hypothesised that stress echocardiography (SE), may be superior to exercise ECG (ExECG), for predicting CAD and outcome, and cost-beneficial, when performed as initial [...]
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Transthoracic Doppler-echocardiography (TTE) can estimate mean pulmonary arterial pressure (MPAP) and pulmonary capillary wedge pressure (PCWP) reliably, and cardiac magnetic [...]
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Quantitative imaging analyses showed an earlier septal wall involvement in hypertension. We planned to determine the effect of hypertension on regional myocardial performance [...]
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Dual antiplatelet treatment (DAPLT) for at least 12 months is recommended after drug eluting stent (DES) implantation, but concerns regarding the extended use of this treatment [...]
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Cardiac rehabilitation (CR) improves cardiac function and exercise capacity in patients with cardiovascular disease (CVD). Simpler techniques are needed for use by physicians [...]
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The management of mitral regurgitation (MR) is challenging — patients may be asymptomatic, oligosymptomatic, older with comorbidities, or clinically symptomatic and not [...]
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In patients with heart disease, the presence of a fragmented QRS complex (fQRS) on the surface electrocardiogram (ECG) is associated with an increased risk of mortality. We [...]
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AL amyloidosis and multiple myeloma result in extracellular deposition of insoluble fibrillary protein in tissue and organs. Untreated median survival is very poor, and even [...]
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One of the most challenging issues of chronic Chagas disease is to provide earlier detection of heart involvement. Two-dimensional speckle tracking (2-D ST) echocardiography, [...]
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Following the development of breakthrough techniques for percutaneous coronary intervention (PCI) in the treatment of chronic total occlusions (CTO), the initial success rate [...]
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Chronotropic incompetence (CI), an attenuated heart rate (HR) response to exercise, is common in patients with cardiovascular disease. The aim of this study was to assess [...]
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The impact of nicorandil as adjunctive therapy for percutaneous coronary intervention (PCI) in patients with ST-elevation myocardial infarction (STEMI) is controversial. We [...]
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Patients exposed to benfluorex have an increased risk of restrictive organic valvular heart disease. Aortic and mitral regurgitations caused by fibrotic valve disease are [...]
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Extracellular vesicles (EVs) are thought to exert protective effects after ischemic and remote ischemic preconditioning. It is not well understood which EV content factors [...]
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We retrospectively investigated our hypothesis that pre-percutaneous coronary intervention (PCI) procedural therapeutic hypothermia may have clinical advantages in patients [...]
Abstract
Cigarette smoking promotes vascular endothelial damage and accelerates progression of atherosclerosis. The purpose of this study was to examine whether the circulating level [...]
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This study sought to investigate the clinical utility of aortic valve calcium score (AVCS) determined by using cardiac multislice computed tomography (MSCT). Data of 1315 [...]
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This was a prospective, single-center study evaluating the efficacy and cost-effectiveness of early ambulation (within 30 min) following femoral artery closure with the ProGlide® [...]
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To evaluate in vivo the feasibility and safety of renal sympathetic denervation (RSD) with different catheters and various radiofrequency protocols. Twenty-two pigs were included. [...]
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Mice are frequently used in research to examine outcomes of myocardial infarction (MI) and to investigate therapeutic interventions at an early pre-clinical stage. The MI [...]
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The IMMEDIATE Trial of emergency medical service use of intravenous glucose–insulin–potassium (GIK) very early in acute coronary syndromes (ACS) showed benefit for the [...]
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Calcified amorphous tumor (CAT) of the heart is a rare non-neoplastic intracavitary cardiac mass. Several case reports have been published but large series are lacking. To [...]
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Altitude-hypoxia induces pulmonary arterial hypertension and altered cardiac morphology and function, which is little known in healthy children at high altitude. We compared [...]
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Fibrosing mediastinitis (FM) is a rare but fatal disease characterized by an excessive fibrotic reaction in the mediastinum, which can lead to life-threatening stenosis of [...]
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A bicuspid aortic valve (BAV) is associated with accelerated aortic valve disease (AVD) and abnormalities in aortic elasticity. We investigated the intima-media thickness [...]
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Exertional angina in patients with no coronary flow limiting lesions remains a clinical puzzle. We aimed to assess the extent of coronary artery calcification (CAC) and its [...]