• Z. Shen, J. Shao, J. Dai, Y. Lin, X. Yang, J. Ma, Q. He, B. Yang, K. Yao, P. Luo
    (2016). Vol. 3

    Abstract
    Visual impairment is a global public health problem that needs new candidate drugs. Chrysanthemum is a traditional Chinese drug, famous for its eye-protective function, with [...]

  • Z. Farooqui, M. Afsar, S. Rizwan, A. Khan, F. Khan
    (2016). Vol. 3

    Abstract
    Cisplatin (CP) is a potent anti-cancer drug widely used against solid tumors. However, it exhibits pronounced adverse effects including hepatotoxicity. Several strategies [...]

  • Y. Iizuka, H. Kim, M. Nakasatomi, T. Izawa, S. Hirako, A. Matsumoto
    (2016). Vol. 3

    Abstract
    Pioglitazone, a thiazolidinedione (TZD), is widely used as an insulin sensitizer in the treatment of type 2 diabetes. However, body weight gain is frequently observed in TZD-treated [...]

  • Y. Cherkas, M. McMillian, D. Amaratunga, N. Raghavan, J. Sasaki
    (2016). Vol. 3

    Abstract
    As legacy toxicogenomics databases have become available, improved data mining approaches are now key to extracting and visualizing subtle relationships between toxicants [...]

  • X. Jin, R. Ray, P. Ray
    (2016). Vol. 3

    Abstract
    Protease stimulation in cultured normal human epidermal keratinocytes (NHEK) due to sulfur mustard (SM) exposure is well documented. However, the specific protease(s) stimulated [...]

  • M. Ramirez-Mares, H. Kobayashi, E. Mejia
    (2016). Vol. 3

    Abstract
    In vitro cell proliferation, cell cycle arrest and induction of apoptosis were investigated, using three human head and neck squamous cell carcinoma (HNSCC) cell lines (OSCC-3, [...]

  • T. Umezu, Y. Shibata
    (2016). Vol. 3

    Abstract
    Bupropion (BUP), a substituted phenyl-ethylamine, has been utilized for the treatment of depression and for smoking cessation, however, one concern is that BUP may increase [...]

  • S. Moon, W. Choi, S. Choi, E. Kim, J. Kim, J. Lee, S. Kim
    (2016). Vol. 3

    Abstract
    We report anti-cancer activity of ZnO thin-film-coated chips by sustained release of zinc ions. ZnO chips were fabricated by precisely tuning ZnO thickness using atomic layer [...]

  • S. Miltonprabu, N. Nazimabashir, V. Manoharan
    (2016). Vol. 3

    Abstract
    The present study was undertaken to evaluate the possible ameliorative role of grape seed proanthocyanidins (GSP) against Cadmium (Cd) induced hepatic inflammation, apoptosis [...]

  • S. Mitazaki, M. Hashimoto, Y. Matsuhashi, S. Honma, M. Suto, N. Kato, K. Hiraiwa, M. Yoshida, S. Abe
    (2016). Vol. 3

    Abstract
    To determine the physiological role of estrogen in the development of liver injury, we examined the sensitivities of sham and ovariectomy (ovx) mice against doxycycline (DOXY)-induced [...]

  • S. Sarkhel
    (2016). Vol. 3

    Abstract
    Quillaja saponaria bark contains a high percentage of triterpene saponins and has been used for centuries as antiinflammatory and analgesic agent in Chilean folk medicine. [...]

  • T. Sarkar, M. Alam, N. Parvin, Z. Fardous, A. Chowdhury, S. Hossain, M. Haque, N. Biswas
    (2016). Vol. 3

    Abstract
    This study is aimed to assess the heavy metals contamination and health risk in Shrimp (Macrobrachium rosenbergii and Penaeus monodon ) collected from Khulna-Satkhira region [...]

  • E. Filho, P. Ávila, C. Bastos, A. Batista, L. Naves, R. Marreto, E. Lima, E. Mendonça, M. Valadares
    (2016). Vol. 3

    Abstract
    Intestinal mucositis is a frequent limiting factor in anticancer therapy and there is currently no broadly effective treatment targeted to cure this side effect. This study [...]

  • M. Cruz, S. Barroso, J. Navoni, M. Teles, J. Barbosa-Filho, H. Rocha, V. Amaral
    (2016). Vol. 3

    Abstract
    Hecogenin is a sapogenin found in Agave species in high quantities and is responsible for the many therapeutic effects of these medicinal plants. In addition, this compound [...]

  • S. Benhamed, F. Guardiola, S. Martínez, M. Martínez-Sánchez, C. Pérez-Sirvent, M. Mars, M. Esteban
    (2016).

    Abstract
    Heavy metals incidence in the aquatic environment and its accumulation in fish are under constant review. Gilthead seabream (Sparus aurata ) specimens were exposed for two [...]

  • S. Sahu
    (2016). Vol. 3

    Abstract
    Extensive consumer exposure to food- and cosmetics-related consumer products containing nanosilver is of public safety concern. Therefore, there is a need for suitable in [...]

  • S. Yoshie, Y. Ogasawara, M. Ikehata, K. Ishii, Y. Suzuki, K. Wada, K. Wake, S. Nakasono, M. Taki, C. Ohkubo
    (2016). Vol. 3

    Abstract
    The embryotoxic effect of intermediate frequency (IF) magnetic field (MF) was evaluated using murine embryonic stem (ES) cells and fibroblast cells based on the embryonic [...]

  • G. Roberts, M. Stout, B. Sayers, D. Fallacara, M. Hejtmancik, S. Waidyanatha, M. Hooth
    (2016).

    Abstract
    The National Toxicology Program (NTP) performed short-term toxicity studies of tetra- and pentavalent vanadium compounds, vanadyl sulfate and sodium metavanadate, respectively. [...]

  • G. Reddy, F. Antwi, G. Shrestha, T. Kuriwada
    (2016). Vol. 3

    Abstract
    The alfalfa weevil, Hypera postica (Coleoptera: Curculionidae), is a major pest of alfalfa Medicago sativa L. (Fabaceae). While H. postica usually causes the most damage before [...]

  • P. Reckziegel, V. Dias, D. Benvegnú, N. Boufleur, R. Barcelos, H. Segat, C. Pase, C. Santos, É. Flores, M. Bürger
    (2016). Vol. 3

    Abstract
    The effect of the antioxidant gallic acid (GA) on Pb toxicity in blood, liver and kidney was investigated in the present study. Rats Wistar received Pb nitrate (50 mg/Kg/day, [...]

  • S. Rebholz, T. Jones, R. Herrick, C. Xie, A. Calafat, S. Pinney, L. Woollett
    (2016).

    Abstract
    Perfluorooctanoic acid (PFOA) is a man-made surfactant with a number of industrial applications. It has a long half-life environmentally and biologically. Past studies suggest [...]

  • B. Hsu, S. Fu
    (2016). Vol. 3

    Abstract
    The aim of this study was to investigate the effect of a glucagon-like peptide-1 receptor agonist (GLP-1RA), exenatide, on clozapine-associated glucose dysregulation in mice. [...]

  • R. Kumar, T. Banerjee
    (2016).

    Abstract
    The impact of sublethal toxicity of sodium arsenite on hematological and certain biochemical parameters of the fresh water catfish Clarias batrachus has been analyzed following [...]

  • Q. Le, K. Tabuchi, A. Hara
    (2016). Vol. 3

    Abstract
    Ceramide-1-phosphate (C1P) is a phosphorylated form of ceramide. While ceramide is known to be an inducer of apoptosis of cochlear hair cells in cisplatin ototoxicity, little [...]

  • B. Qaqish, O. Al-Dalahmah, Y. Al-Motassem, A. Battah, S. Ismail
    (2016).

    Abstract
    An increased incidence of non-Hodgkin’s lymphoma (NHL) has been reported in farmers and other occupational groups working with pesticides. In these individuals, an increased [...]

  • O. Oyenihi, B. Afolabi, A. Oyenihi, O. Ogunmokun, O. Oguntibeju
    (2016).

    Abstract
    Chronic and acute alcohol exposure has been extensively reported to cause oxidative stress in hepatic and extra-hepatic tissues. Watermelon (Citrullus lanatus ) is known to [...]

  • O. Azu, A. Jegede, O. Ugochukwu, I. Onanuga, S. Kharwa, E. Naidu
    (2016). Vol. 3

    Abstract
    As the roll-out of antiretroviral therapy continues to drive downwards morbidity and mortality in people living with HIV/AIDS (PLWHAs), organ toxicities (especially the liver) [...]

  • E. Nwaichi, S. Ntorgbo
    (2016). Vol. 3

    Abstract
    Levels of sixteen polycyclic aromatic hydrocarbons (PAHs) in 30 edible tissues of selected frequently-consumed fish and seafood collected from three coastal waters of Niger [...]

  • N. Hashizume, Y. Oshima, M. Nakai, T. Kobayashi, T. Sasaki, K. Kawaguchi, K. Honda, M. Gamo, K. Yamamoto, Y. Tsubokura, S. Ajimi, Y. Inoue, N. Imatanaka
    (2016). Vol. 3

    Abstract
    A potentially useful means of predicting the pulmonary risk posed by new forms of nano-structured titanium dioxide (nano-TiO2 ) is to use the associations between the physicochemical [...]

  • N. Friedel, D. Scolnik, D. Adir, M. Glatstein
    (2016). Vol. 3

    Abstract
    We present a 15-year-old female patient with an anaphylactic reaction to a jellyfish sting, sustained while surfing in the Mediterranean Sea. She experienced immediate difficulty [...]

  • M. Allegri, D. Perivoliotis, M. Bianchi, M. Chiu, A. Pagliaro, M. Koklioti, A. Trompeta, E. Bergamaschi, O. Bussolati, C. Charitidis
    (2016).

    Abstract
    The elucidation of toxicity determinants of multi-walled carbon nanotubes (MWCNT) is still incomplete. Functionalization with carboxyl groups is, however, commonly used to [...]

  • D. Mwalwayo, B. Thole
    (2016). Vol. 3

    Abstract
    A study was carried out to assess levels of contamination of aflatoxins and fumonisins (B1 + B2 ) in maize produced, stored and consumed in rural households in Malawi. A total [...]

  • M. Mossoba, T. Flynn, S. Vohra, P. Wiesenfeld, R. Sprando
    (2016).

    Abstract
    Adhatoda zeylanica is a dietary supplement ingredient present in several types of dietary supplements, including weight loss, respiratory relief, and immune regulating products. [...]

  • R. Matulka, T. Chan, R. Green, J. Carney, S. Franklin, P. Licari
    (2016). Vol. 3

    Abstract
    Microalgae are increasingly being utilized as food ingredients for a variety of applications, including as sources of protein, egg and dairy substitutes, and cooking oils. [...]

  • C. Mattison, Y. Bren-Mattison, B. Vant-Hull, A. Vargas, R. Wasserman, C. Grimm
    (2016).

    Abstract
    Cashew nuts are an increasingly common cause of food allergy. We compare the soluble protein profile of cashew nuts following heating. SDS-PAGE indicate that heating can alter [...]

  • R. Maronpot, C. Hobbs, J. Davis, C. Swartz, M. Boyle, M. Koyanagi, S. Hayashi
    (2016). Vol. 3

    Abstract
    Microbiologically derived cyclodextrin glucanotransferase (CGTase) is used commercially as a processing agent in manufacture of food, pharmaceuticals, and cosmetics. Its toxic [...]

  • L. Søfteland, M. Berntssen, J. Kirwan, T. Størseth, M. Viant, B. Torstensen, R. Waagbø, P. Olsvik
    (2016).

    Abstract
    Extended use of plant ingredients in Atlantic salmon farming has increased the need for knowledge on the effects of new nutrients and contaminants in plant based feeds on [...]

  • L. Vijayasteltar, G. Nair, B. Maliakel, R. Kuttan, K. I.M.
    (2016). Vol. 3

    Abstract
    Despite the various reports on the toxicity of clove oil and its major component eugenol, systematic evaluations on the safety of polyphenolic extracts of clove buds have [...]

  • S. Lelli, M. Mazzetti, L. Viale
    (2016).

    Abstract
    This work investigated the modulation by melatonin (Mel) of the effects of the porphyrinogenic drugs 2-allyl-2-isopropylacetamide (AIA) and 3, 5-diethoxycarbonyl-1, 4-dihydro-2, [...]

  • L. Dolan, R. Matulka, J. Worn, J. Nizio
    (2016). Vol. 3

    Abstract
    Use of pecan shell fiber in human food is presently limited, but could increase pending demonstration of safety. In a 91-day rat study, pecan shell fiber was administered [...]

  • L. Takser, N. Benachour, B. Husk, H. Cabana, D. Gris
    (2016). Vol. 3

    Abstract
    Cyanotoxins have been shown to be highly toxic for mammalian cells, including brain cells. However, little is known about their effect on inflammatory pathways. This study [...]

  • W. Klaren, S. Flor, K. Gibson-Corley, G. Ludewig, L. Robertson
    (2016). Vol. 3

    Abstract
    Polychlorinated biphenyls (PCBs), industrial chemicals and persistent environmental pollutants, are found in rural and urban settings. Rodent studies have shown that exposure [...]

  • K. Lien, D. Hsieh, H. Huang, C. Wu, S. Ni, M. Ling
    (2016). Vol. 3

    Abstract
    The purpose of this study was to assess the health risk associated with dietary intake of sulfites for Taiwanese general consumers by conducting a total diet study (TDS). [...]

  • D. Karanewsky, A. Arthur, H. Liu, B. Chi, L. Ida, S. Markison
    (2016). Vol. 3

    Abstract
    A toxicological evaluation of a umami flavour compound, 2-(((3-(2, 3-dimethoxyphenyl)-1H -1, 2, 4-triazol-5-yl)thio)methyl)pyridine (S3643, CAS 902136-79-2), was completed [...]

  • D. Jones
    (2016). Vol. 3

    Abstract
    The exposome is a complement to the genome that includes non-genetic causes of disease. Multiple definitions are available, with salient points being global inclusion of exposures [...]

  • J. Bai, P. Lei, C. Zhao, Y. Wang, D. Yan, S. Yang
    (2016). Vol. 3

    Abstract
    This study investigated the effects of Na2 SO3 on the fat metabolism in human normal diploid HL-7702 (referred as L-02) hepatocytes. After 24 h and 48 h, treatment with different [...]

  • C. Iwegbue, F. Bassey, G. Obi, G. Tesi, B. Martincigh
    (2016).

    Abstract
    The concentrations of nine metals (Cd, Pb, Ni, Cr, Co, Cu, Fe, Mn and Zn) were determined in lip sticks, lip glosses, lip balms, eye pencils, eyeliners, eye shadows, blushes, [...]

  • S. Ivanović, B. Dimitrijević, V. Ćupić, M. Jezdimirović, S. Borozan, M. Savić, D. Savić
    (2016). Vol. 3

    Abstract
    Diazinon (DZN) is an organophosphate insecticide which exerts its effect through the inhibition of acetylcholinesterase enzyme (AChE). In this work, we studied the development [...]

  • F. Solmaz, E. Gündoğdu, D. Akduman, M. Haksever, O. Dikici, F. Ünal
    (2016). Vol. 3

    Abstract
    Aminoglycosides (AGs) have been widely used for potential life-threatening bacterial infections. Although AGs are well known for their ototoxic side effects, some AGs such [...]

  • L. Felix, J. Perez, M. Contreras, T. Ravasi, J. Kosel
    (2016).

    Abstract
    The increasing interest in the use of magnetic nanostructures for biomedical applications necessitates rigorous studies to be carried out in order to determine their potential [...]

  • D. Monte, J. Tenório, I. Bastos, F. Mendonça, J. Neto, T. Silva, C. Ramos
    (2016).

    Abstract
    Considering the increase in consumption of Cannabis sativa and the use of the compound β- carotene (BC) as supplement, we investigated potential changes in the chemical and [...]

  • C. Bastos, P. Ávila, E. Filho, R. Ávila, A. Batista, S. Fonseca, E. Lima, R. Marreto, E. Mendonça, M. Valadares
    (2016).

    Abstract
    Several studies towards the development of an effective treatment for intestinal mucositis have been reported, since this condition represents a major problem in clinical [...]

  • R. Collí-Dulá, M. Friedman, B. Hansen, N. Denslow
    (2016). Vol. 3

    Abstract
    Acrylamide is known to produce follicular cell tumors of the thyroid in rats. RccHan Wistar rats were exposed in utero to a carcinogenic dose of acrylamide (3 mg/Kg bw/day) [...]

  • C. Gao, Z. He, J. Li, X. Li, Q. Bai, Z. Zhang, X. Zhang, S. Wang, X. Xiao, F. Wang, Y. Yan, D. Li, L. Chen, X. Zeng, Y. Xiao, G. Dong, Y. Zheng, Q. Wang, W. Chen
    (2016). Vol. 3

    Abstract
    To explore whether the alteration of lncRNA expression is correlated with polycyclic aromatic hydrocarbons (PAHs) exposure and DNA damage, we examined PAHs external and internal [...]

  • S. Borghoff, D. Wikoff, S. Harvey, L. Haws
    (2016). Vol. 3

    Abstract
    Tetrabromobisphenol A (TBBPA), a nongenotoxic flame retardant, causes uterine tumors in female rats. A proposed mode of action (MoA) for these tumors involves an increase [...]

  • B. Ramachandran, S. Jayavelu, K. Murhekar, T. Rajkumar
    (2016). Vol. 3

    Abstract
    EGCG (Epigallocatechin-3-gallate) is the major active principle catechin found in green tea. Skepticism regarding the safety of consuming EGCG is gaining attention, despite [...]

  • L. Bain, J. Liu, R. League
    (2016). Vol. 3

    Abstract
    Millions of people are exposed to arsenic through their drinking water and food, but the mechanisms by which it impacts embryonic development are not well understood. Arsenic [...]

  • A. Ghosh, S. Banerjee, A. Mitra, M. Muralidharan, B. Roy, R. Banerjee, A. Mandal, I. Chatterjee
    (2016). Vol. 3

    Abstract
    Cigarette smoke (CS) is an important source of morbidity and early mortality worldwide. Besides causing various life-threatening diseases, CS is also known to cause hypoxia. [...]

  • A. Eisenkraft, A. Falk
    (2016). Vol. 3

    Abstract
    Organophosphates (OPs) are cholinesterase inhibitors that lead to a characteristic toxidrome of hypersecretion, miosis, dyspnea, respiratory insufficiency, convulsions and, [...]

  • A. Atilano-Roque, X. Wen, L. Aleksunes, M. Joy
    (2016). Vol. 3

    Abstract
    Cisplatin is a chemotherapeutic agent used in the treatment of solid tumors, with clinical use often complicated by kidney toxicity. Nuclear factor (erythroid-derived-2)-like [...]

  • A. Sani, M. Idris
    (2016). Vol. 3

    Abstract
    The constant discharge of agricultural waste into aquatic environment has led to accumulation of heavy chemicals and other variety of pollutants. Herbicides present in these [...]

  • A. Asmari, H. Shahrani, N. Masri, A. Faraidi, I. Elfaki, M. Arshaduddin
    (2016). Vol. 3

    Abstract
    Vanillin is commonly used as an additive in food, medicine and cosmetics, but its effect has not yet been studied in gastric injury. Therefore the effect of vanillin was studied [...]

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