Abstract

The current scientific understanding of adolescent depression is incomplete, requiring further research and attention. This review of Selective Serotonin Reuptake Inhibitors (SSRIs) in the context of adolescent depression seeks to inform adolescents about the mechanisms in which SSRIs affect the body, common side effects associated with this class of antidepressants, and the efficacy rates of SSRIs in their population group. This review also underscores the gaps in research regarding both adolescent depression and adolescent antidepressant usage. When considering the use of prescription drugs, especially ones that have large implications towards neurological function, it is essential to understand all facets of the medication. This review provides adolescents and their families with direct information that will inform their thinking about SSRI use. This review considers academic and popular sources in collating evidence for the impact and efficacy of SSRIs on adolescents. Through careful analysis of the consequences and benefits associated with SSRI usage, this review provides a comprehensive scientific overview of SSRIs. To inform adolescents and their families, this review will first offer a mechanistic overview of the SSRI drug class, next evaluate evidence for the neurological effects of SSRIs on the adolescent brain, and then highlight clinical testing of two specific SSRIs, Fluoxetine and Escitalopram. Both the implications of SSRIs on adolescent brain development and their possible short-term and long-term negative side effects are considered in this review. Most importantly, this review draws attention to the multitude of unknowns surrounding SSRI usage in adolescents and urges researchers to continue evaluating the implications of early antidepressant usage. With an adolescent centered viewpoint and a focus on extensivity, this report provides adolescents and their families with the resources to make personalized decisions about SSRI exposure.