Bangladesh has reported repeated outbreaks of highly pathogenic avian inﬂuenza (HPAI) A(H5) viruses in poultry since 2007. Because of the large number of live poultry markets (LPM) relative to the population density of poultry throughout the country, these markets can serve as sentinel sites for HPAI A(H5) detection. Through active LPM surveillance during June 2016–June 2017, HPAI A(H5N6) viruses along with 14 other subtypes of inﬂuenza A viruses were detected. The HPAI A(H5N6) viruses belonged to clade 188.8.131.52 and were likely introduced into Bangladesh around March 2016. Human infections with inﬂuenza clade 184.108.40.206 viruses in Bangladesh have not been identiﬁed, but the viruses had several molecular markers associated with potential human infection. Vigilant surveillance at the animal-human interface is essential to identify emerging avian inﬂuenza viruses with the potential to threaten public and animal health.