A virtual calibration chamber was built using a threedimensional model based on the discrete-element method. The chamber was then filled with a scaled granular equivalent of Ticino sand, the material properties of which were selected by curve-fitting triaxial tests. Cone penetration tests were then performed under different initial densities and isotropic stresses. Penetration resistance in the virtual calibration chamber was affected by the same cone/chamber size effect that affects physical calibration chambers and was corrected accordingly. The corrected cone resistance obtained from the virtual calibration chamber cone penetration tests shows good quantitative agreement with correlations that summarise previous physical results.