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Abstract

Viruses have gained a notoriously bad reputation as infectious agents, but they are nonetheless fascinating for biologists, not least because they are the most numerous and fastest evolving organisms on the planet. Moreover, viruses have had a significant role in the evolution of all other organisms, from bacteria through vertebrates to humans. But the full extent of this role is only just emerging, and scientists are reappraising not just the relationship between viruses and their hosts, but also the main principle of evolution: that it operates largely on the basis of gene mutation coupled with selection. > …viruses have had a significant role in the evolution of all other organisms, from bacteria through vertebrates to humans In fact, infectivity is only the tip of the viral iceberg, and cohabitation is actually the norm—as is the case for bacteria. Similarly to bacteria and other microorganisms, most viruses and their hosts have co‐evolved either into commensal relationships where the parasite's impact is neutral, or into mutually beneficial symbiotic arrangements. Of course, for viruses there is also the additional genomic dimension: they insert themselves into the host's DNA and in doing so can generate novel proteins and RNA molecules that might be valuable to the host. Moreover, it also allows the virus to manipulate the host genomic structure itself. Although this ability could wreak potential genetic havoc, it might also trigger significant structural and functional changes in the host genome that could not occur through random mutation alone. Viruses have the unique ability to incorporate themselves permanently into the genomes of their hosts—a phenomenon known as endogenization—and thus lose their ability to infect other individuals. In return, they gain immortality, as they are passed down to successive generations of hosts. Yet, although no other microorganisms can invade the genome, endogenization has a parallel among …


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The different versions of the original document can be found in:

http://dx.doi.org/10.1093/nq/s10-ii.42.317g
http://dx.doi.org/10.1093/nq/s8-vi.154.447h
http://dx.doi.org/10.3167/trans.2015.050305
https://academic.microsoft.com/#/detail/2946636962
https://academic.microsoft.com/#/detail/2510223383
http://journals.sagepub.com/doi/full-xml/10.1177/2158244012455179,
http://dx.doi.org/10.1177/2158244012455179 under the license http://journals.sagepub.com/page/policies/text-and-data-mining-license
http://dx.doi.org/10.1007/978-1-4613-0195-0_19
http://dx.doi.org/10.1007/978-3-319-00095-4_8
http://link.springer.com/article/10.1007/BF02926183/fulltext.html,
http://link.springer.com/content/pdf/10.1007/BF02926183,
http://dx.doi.org/10.1007/bf02926183 under the license http://www.springer.com/tdm
http://link.springer.com/article/10.1007/BF03024304/fulltext.html,
http://link.springer.com/content/pdf/10.1007/BF03024304,
http://dx.doi.org/10.1007/bf03024304 under the license http://www.springer.com/tdm
http://doi.acm.org/10.1145/242417.242462,
http://dl.acm.org/citation.cfm?id=242462,
https://academic.microsoft.com/#/detail/2031195881
http://dx.doi.org/10.1215/00182702-7023554
https://dblp.uni-trier.de/db/conf/chi/chi2000a.html#Nemetz00,
http://portal.acm.org/citation.cfm?doid=633292.633333,
https://dl.acm.org/citation.cfm?doid=633292.633333,
http://doi.org/10.1145/633292.633333,
https://doi.acm.org/10.1145/633292.633333,
https://dl.acm.org/citation.cfm?id=633333,
https://academic.microsoft.com/#/detail/2074965127
http://www.emeraldinsight.com/doi/full/10.1108/02630800010322490,
http://dx.doi.org/10.1108/02630800010322490 under the license http://www.emeraldinsight.com/page/tdm
http://www.emeraldinsight.com/doi/full/10.1108/EUM0000000004022,
http://dx.doi.org/10.1108/eum0000000004022 under the license http://www.emeraldinsight.com/page/tdm
https://dblp.uni-trier.de/db/conf/icfp/icfp2006.html#Rossberg06,
https://doi.acm.org/10.1145/1159803.1159816,
https://www.ps.uni-saarland.de/Publications/documents/missing-link.pdf,
https://dl.acm.org/citation.cfm?doid=1159803.1159816,
https://academic.microsoft.com/#/detail/2039446670
http://www.nature.com/articles/35096029,
http://dx.doi.org/10.1038/35096029 under the license http://www.springer.com/tdm
http://www.nature.com/articles/419121a,
http://dx.doi.org/10.1038/419121a under the license http://www.springer.com/tdm
http://www.nature.com/articles/nrmicro1112,
http://dx.doi.org/10.1038/nrmicro1112 under the license http://www.springer.com/tdm
http://www.nature.com/articles/nrn2549,
http://dx.doi.org/10.1038/nrn2549 under the license http://www.springer.com/tdm
http://www.nature.com/articles/nrn2904,
http://dx.doi.org/10.1038/nrn2904 under the license http://www.springer.com/tdm
http://www.nature.com/articles/s42254-019-0021-y.pdf,
http://dx.doi.org/10.1038/s42254-019-0021-y under the license http://www.springer.com/tdm
https://academic.microsoft.com/#/detail/1991082468
https://academic.microsoft.com/#/detail/2011175811
https://insights.ovid.com/patient-safety/jpats/2010/09/000/missing-link-dedicated-patient-safety-education/7/01209203,
https://academic.microsoft.com/#/detail/2319062347
http://dx.doi.org/10.1080/01619565409536521
http://dx.doi.org/10.1080/03087298.1982.10443053
https://api.elsevier.com/content/article/PII:0002937878902624?httpAccept=text/plain,
http://dx.doi.org/10.1016/0002-9378(78)90262-4 under the license https://www.elsevier.com/tdm/userlicense/1.0/
https://api.elsevier.com/content/article/PII:0047248475900901?httpAccept=text/plain,
http://dx.doi.org/10.1016/0047-2484(75)90090-1 under the license https://www.elsevier.com/tdm/userlicense/1.0/
https://api.elsevier.com/content/article/PII:S0033318283731646?httpAccept=text/plain,
http://dx.doi.org/10.1016/s0033-3182(83)73164-6 under the license https://www.elsevier.com/tdm/userlicense/1.0/
https://api.elsevier.com/content/article/PII:S0140673610619423?httpAccept=text/plain,
http://dx.doi.org/10.1016/s0140-6736(10)61942-3 under the license https://www.elsevier.com/tdm/userlicense/1.0/
https://onlinelibrary.wiley.com/doi/pdf/10.1038/embor.2008.152,
https://onlinelibrary.wiley.com/doi/full-xml/10.1038/embor.2008.152,
http://dx.doi.org/10.1038/embor.2008.152 under the license http://onlinelibrary.wiley.com/termsAndConditions#vor
https://onlinelibrary.wiley.com/doi/pdf/10.1038/embor.2009.267,
https://onlinelibrary.wiley.com/doi/full-xml/10.1038/embor.2009.267,
http://dx.doi.org/10.1038/embor.2009.267 under the license http://onlinelibrary.wiley.com/termsAndConditions#vor
http://dx.doi.org/10.1113/expphysiol.1968.sp001939 under the license http://doi.wiley.com/10.1002/tdm_license_1.1
https://brill.com/downloadpdf/journals/joup/23/1-2/article-p82_82.xml,
http://dx.doi.org/10.1163/18754112-20200002
https://academic.microsoft.com/#/detail/3035474450
https://onlinelibrary.wiley.com/doi/full/10.1002/9781118324905.ch23,
https://academic.microsoft.com/#/detail/2554829010
https://ui.adsabs.harvard.edu/abs/2002Natur.419..121K/abstract,
https://authors.library.caltech.edu/56181,
https://academic.microsoft.com/#/detail/2029318958
https://academic.microsoft.com/#/detail/2316250915
http://eprints.ioe.ac.uk/17047,
https://academic.microsoft.com/#/detail/2169218304
http://dx.doi.org/10.1049/ee.1996.0013
http://dx.doi.org/10.1049/me:19970504
http://dx.doi.org/10.1145/1145660.1145666
http://dx.doi.org/10.1145/242417.242462
http://dx.doi.org/10.1145/633332.633333
https://doaj.org/toc/2158-2440
http://documents.worldbank.org/curated/en/182011468238758121/The-missing-link-fostering-positive-citizen-state-relations-in-post-conflict-environments,
https://academic.microsoft.com/#/detail/2106028128
https://hal-amu.archives-ouvertes.fr/hal-01310268/document,
https://hal-amu.archives-ouvertes.fr/hal-01310268/file/17_raoult.pdf
https://academic.microsoft.com/#/detail/2210192064
https://journals.sagepub.com/doi/full/10.1177/2158244012455179,
https://core.ac.uk/display/89832975,
https://academic.microsoft.com/#/detail/2335606326
http://dx.doi.org/10.1002/9781118324905.ch23
https://pubs.nctm.org/downloadpdf/journals/at/23/6/article-p410.xml,
http://dx.doi.org/10.5951/at.23.6.0410
https://academic.microsoft.com/#/detail/2954397341
https://academic.microsoft.com/#/detail/2925065504
http://ro.uow.edu.au/cgi/viewcontent.cgi?article=3376&context=lhapapers,
https://www.berghahnjournals.com/view/journals/transfers/5/3/trans050305.xml,
https://academic.microsoft.com/#/detail/2331403117
http://dx.doi.org/10.1136/bmj.2.5191.39-a
http://www-ihm.lri.fr/~mackay/pdffiles/IHM03.Mixed.Reality.pdf,
https://dblp.uni-trier.de/db/conf/ihm/ihm2003.html#Mackay03,
http://insitu.lri.fr/~mackay/pdffiles/IHM03.Mixed.Reality.pdf,
https://dl.acm.org/citation.cfm?id=1063671,
http://www.lri.fr/~mackay/pdffiles/IHM03.Mixed.Reality.pdf,
https://academic.microsoft.com/#/detail/2148253596
https://academic.microsoft.com/#/detail/2017838652
http://europepmc.org/articles/PMC2816630,
https://embor.embopress.org/content/11/1/28.abstract,
https://academic.microsoft.com/#/detail/2256016715
http://europepmc.org/abstract/MED/5185322,
https://academic.microsoft.com/#/detail/2412245970
https://www.ncbi.nlm.nih.gov/pubmed/637110,
https://academic.microsoft.com/#/detail/2340832445
https://academic.microsoft.com/#/detail/173887553
https://www.ncbi.nlm.nih.gov/pubmed/22230627,
https://academic.microsoft.com/#/detail/254443532
https://academic.microsoft.com/#/detail/3023908038
http://dx.doi.org/10.1145/1063669.1063671
http://dx.doi.org/10.1145/1159803.1159816
http://dx.doi.org/10.1145/1160074.1159816
http://dx.doi.org/10.1145/633292.633333
  • [ ]


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Published on 31/12/14
Accepted on 31/12/14
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Volume 2015, 2015
DOI: 10.1038/embor.2008.152
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