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==Summary==
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Drug-eluting stents were developed to counteract the severe restenosis observed after bare-metal stent implantation. The risk of restenosis still prevailed due to the inhibitory effect of the drug on endothelial healing. The current work focuses on extending a multiphysics-based modeling framework to include the effect of anti-inflammatory drugs embedded in the drugeluting stents. An additional advection-reaction-diffusion equation governing the drug transport is introduced herein. Additionally, the effect of drugs, specifically rapamycin-based ones, on the proliferation of smooth muscle cells is captured. An optimal level of drug embedment is realized through the modeling framework.
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Published on 24/11/22
Accepted on 24/11/22
Submitted on 24/11/22

Volume Computational Solid Mechanics, 2022
DOI: 10.23967/eccomas.2022.004
Licence: CC BY-NC-SA license

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