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==Summary==
Drug-eluting stents were developed to counteract the severe restenosis observed after bare-metal stent implantation. The risk of restenosis still prevailed due to the inhibitory effect of the drug on endothelial healing. The current work focuses on extending a multiphysics-based modeling framework to include the effect of anti-inflammatory drugs embedded in the drugeluting stents. An additional advection-reaction-diffusion equation governing the drug transport is introduced herein. Additionally, the effect of drugs, specifically rapamycin-based ones, on the proliferation of smooth muscle cells is captured. An optimal level of drug embedment is realized through the modeling framework.
Return to Reese et al 2022a.
Published on 24/11/22
Accepted on 24/11/22
Submitted on 24/11/22
Volume Computational Solid Mechanics, 2022
DOI: 10.23967/eccomas.2022.004
Licence: CC BY-NC-SA license
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