Scipediacontent: Scipediacontent moved page Draft Content 432307088 to Maurer et al 2019a

2021-01-28T18:36:31Z

Scipediacontent moved page Draft Content 432307088 to Maurer et al 2019a

Scipediacontent: Created page with " == Abstract == The anesthetic propofol and other exhaled organic compounds can be sampled in Tenax sorbent tubes and analyzed by gas chromatography coupled with mass spectro..."

2021-01-28T18:36:28Z

Created page with " == Abstract == The anesthetic propofol and other exhaled organic compounds can be sampled in Tenax sorbent tubes and analyzed by gas chromatography coupled with mass spectro..."

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== Abstract ==

The anesthetic propofol and other exhaled organic compounds can be sampled in Tenax sorbent tubes and analyzed by gas chromatography coupled with mass spectrometry. The aim of this study was to evaluate the stability of propofol in Tenax sorbent tubes during overseas shipping. This is relevant for international pharmacokinetic studies on propofol in exhaled air. Tenax sorbent tube propofol samples with concentrations between 10 and 100 ng were prepared by liquid injection and with a calibration gas generator. For each preparation method, one reference set was analyzed immediately after preparation, a second set was stored at room temperature, and a third one was stored refrigerated. The fourth set was sent from Germany by airmail to USA and back. The shipped set of tubes was analyzed when it returned after 55 days elapsed. Then, the room temperature samples and the refrigerated stored samples were also analyzed. To evaluate the stability of propofol in the stored and shipped tubes, we calculated the recovery rates of each sample set. The mean recovery in the stored samples was 101.2% for the liquid preparation and 134.6% for the gaseous preparation at 4°C. At 22°C, the recovery was 96.1% for liquid preparation and 92.1% for gaseous preparation, whereas the shipped samples had a recovery of 85.3% and 111.3%. Thus, the deviation of the shipped samples is within a range of 15%, which is analytically acceptable. However, the individual values show significantly larger deviations of up to -32.1% (liquid) and 30.9% (gaseous). We conclude that storage of propofol on Tenax tubes at room temperature for 55 days is possible to obtain acceptable results. However, it appears that due to severe temperature and pressure variations air shipment of propofol samples in Tenax tubes without cooling shows severe deviations from the initial concentration. Although it was not tested in this study, we assume that refrigerated transport might be necessary to obtain comparable results as in the stored samples.

Document type: Article

== Full document ==
<pdf>Media:Draft_Content_432307088-beopen786-2095-document.pdf</pdf>

== Original document ==

The different versions of the original document can be found in:

* [http://downloads.hindawi.com/journals/ijac/2019/3987417.pdf http://downloads.hindawi.com/journals/ijac/2019/3987417.pdf] under the license https://creativecommons.org/licenses/by

* [http://dx.doi.org/10.1155/2019/3987417 http://dx.doi.org/10.1155/2019/3987417] under the license cc-by

* [http://europepmc.org/articles/PMC6521560 http://europepmc.org/articles/PMC6521560] under the license http://creativecommons.org/licenses/by/4.0

* [http://downloads.hindawi.com/journals/ijac/2019/3987417.pdf http://downloads.hindawi.com/journals/ijac/2019/3987417.pdf],
: [http://downloads.hindawi.com/journals/ijac/2019/3987417.xml http://downloads.hindawi.com/journals/ijac/2019/3987417.xml],
: [http://dx.doi.org/10.1155/2019/3987417 http://dx.doi.org/10.1155/2019/3987417]

* [http://dx.doi.org/10.1155/2019/3987417 http://dx.doi.org/10.1155/2019/3987417],
: [https://doaj.org/toc/1687-8760 https://doaj.org/toc/1687-8760],
: [https://doaj.org/toc/1687-8779 https://doaj.org/toc/1687-8779] under the license http://creativecommons.org/licenses/by/4.0/

* [https://www.hindawi.com/journals/ijac/2019/3987417 https://www.hindawi.com/journals/ijac/2019/3987417],
: [http://downloads.hindawi.com/journals/ijac/2019/3987417.pdf http://downloads.hindawi.com/journals/ijac/2019/3987417.pdf],
: [https://www.ncbi.nlm.nih.gov/pubmed/31186644 https://www.ncbi.nlm.nih.gov/pubmed/31186644],
: [https://scidok.sulb.uni-saarland.de/handle/20.500.11880/29224 https://scidok.sulb.uni-saarland.de/handle/20.500.11880/29224],
: [https://publikationen.sulb.uni-saarland.de/bitstream/20.500.11880/29224/1/Research%20Article_Stability%20of%20Propofol%20%282%2c6-Diisopropylphenol%29%20in%20Thermal%20Desorption%20Tubes.pdf https://publikationen.sulb.uni-saarland.de/bitstream/20.500.11880/29224/1/Research%20Article_Stability%20of%20Propofol%20%282%2c6-Diisopropylphenol%29%20in%20Thermal%20Desorption%20Tubes.pdf],
: [https://publikationen.sulb.uni-saarland.de/handle/20.500.11880/29224 https://publikationen.sulb.uni-saarland.de/handle/20.500.11880/29224],
: [https://academic.microsoft.com/#/detail/2943564401 https://academic.microsoft.com/#/detail/2943564401]

* [ ]

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Scipediacontent: Scipediacontent moved page Draft Content 432307088 to Maurer et al 2019a

Scipediacontent: Created page with " == Abstract == The anesthetic propofol and other exhaled organic compounds can be sampled in Tenax sorbent tubes and analyzed by gas chromatography coupled with mass spectro..."