• R. Zhao, B. Choi, M. Lee, A. Bode, Z. Dong
    EBioMedicine (2016). Vol. 8

    Abstract
    Aberrant gene silencing is highly associated with altered cell cycle regulation during carcinogenesis. In particular, silencing of the CDKN2A tumor suppressor gene, which [...]

  • J. Wu, M. Gao, S. Rice, C. Tsang, J. Beggs, D. Turner, G. Li, B. Yang, K. Xia, F. Gao, S. Qiu, Q. Liu, J. Kerrigan
    EBioMedicine (2016). Vol. 8

    Abstract
    Human hypothalamic hamartoma (HH) is a rare subcortical lesion associated with treatment-resistant epilepsy. Cellular mechanisms responsible for epileptogenesis are unknown. [...]

  • . Wei, H. Guo, M. Ma, R. Markham, X. Yu
    EBioMedicine (2016). Vol. 8

    Abstract
    Recent studies have identified human myxovirus resistance protein 2 (MxB or Mx2) as an interferon induced inhibitor of HIV-1 replication. However, whether HIV-1 can overcome [...]

  • V. Walker-Sperling, C. Pohlmeyer, P. Tarwater, J. Blankson
    EBioMedicine (2016).

    Abstract
    Shock and kill strategies involving the use of small molecules to induce viral transcription in resting CD4 + T cells (shock) followed by immune mediated clearance of the [...]

  • L. Vranckx, J. Demeulemeester, S. Saleh, A. Boll, G. Vansant, R. Schrijvers, C. Weydert, E. Battivelli, E. Verdin, A. Cereseto, F. Christ, R. Gijsbers, Z. Debyser
    EBioMedicine (2016). Vol. 8

    Abstract
    Persistence of latent, replication-competent Human Immunodeficiency Virus type 1 (HIV-1) provirus is the main impediment towards a cure for HIV/AIDS (Acquired Immune Deficiency [...]

  • H. Vanderven, F. Ana-Sosa-Batiz, S. Jegaskanda, S. Rockman, K. Laurie, I. Barr, W. Chen, B. Wines, P. Hogarth, T. Lambe, S. Gilbert, M. Parsons, S. Kent
    EBioMedicine (2016).

    Abstract
    The conserved internal influenza proteins nucleoprotein (NP) and matrix 1 (M1) are well characterised for T cell immunity, but whether they also elicit functional antibodies [...]

  • S. Ushiama, Y. Ishimaru, M. Narukawa, M. Yoshioka, C. Kozuka, N. Watanabe, M. Tsunoda, N. Osakabe, T. Asakura, H. Masuzaki, K. Abe
    EBioMedicine (2016). Vol. 8

    Abstract
    Taste signals and nutrient stimuli sensed by the gastrointestinal tract are transmitted to the brain to regulate feeding behavior and energy homeostasis. This system is referred [...]

  • R. Uauy, D. Suri, S. Ghosh, A. Kurpad, I. Rosenberg
    EBioMedicine (2016). Vol. 8

  • K. Tschapalda, Y. Zhang, L. Liu, K. Golovnina, T. Schlemper, T. Eichmann, M. Lal-Nag, U. Sreenivasan, J. McLenithan, S. Ziegler, C. Sztalryd, A. Lass, D. Auld, B. Oliver, H. Waldmann, Z. Li, M. Shen, M. Boxer, M. Beller
    EBioMedicine (2016).

    Abstract
    Excess lipid storage is an epidemic problem in human populations. Thus, the identification of small molecules to treat or prevent lipid storage-related metabolic complications [...]

  • T. Sinnberg, E. Makino, M. Krueger, A. Velic, B. Macek, U. Rothbauer, N. Groll, O. Pötz, S. Czemmel, H. Niessner, F. Meier, K. Ikenberg, C. Garbe, B. Schittek
    EBioMedicine (2016). Vol. 8

    Abstract
    Acquired resistance to second generation BRAF inhibitors (BRAFis), like vemurafenib is limiting the benefits of long term targeted therapy for patients with malignant melanomas [...]

  • Y. Shen, C. Pang, Y. Wu, D. Li, C. Wan, Z. Liao, T. Yang, L. Chen, F. Wen
    EBioMedicine (2016). Vol. 8

    Abstract
    The usefulness of bronchoalveolar lavage fluid (BALF) CD4/CD8 ratio for diagnosing sarcoidosis has been reported in many studies with variable results. Therefore, we performed [...]

  • S. Serrano-Villar, D. Rojo, M. Martínez-Martínez, S. Deusch, J. Vázquez-Castellanos, R. Bargiela, T. Sainz, M. Vera, S. Moreno, V. Estrada, M. Gosalbes, A. Latorre, J. Seifert, C. Barbas, A. Moya, M. Ferrer
    EBioMedicine (2016). Vol. 8

    Abstract
    While changes in gut microbial populations have been described in human immuno-deficiency virus (HIV)-infected patients undergoing antiretroviral therapy (ART), the mechanisms [...]

  • M. Roerecke, R. Nanau, J. Rehm, M. Neuman
    EBioMedicine (2016). Vol. 8

    Abstract
    Fatty liver (hepatic steatosis) is one of the most common diseases globally, with increasing prevalence. The role of alcohol consumption in the development of hepatic steatosis [...]

  • C. Psomas, M. Younas, C. Reynes, R. Cezar, P. Portalès, E. Tuaillon, A. Guigues, C. Merle, N. Atoui, C. Fernandez, V. Moing, C. Barbuat, G. Marin, N. Nagot, A. Sotto, J. Eliaou, R. Sabatier, J. Reynes, P. Corbeau
    EBioMedicine (2016). Vol. 8

    Abstract
    Immune activation in HIV-1-infected individuals is reduced under antiretroviral therapies, but persists, resulting in various morbidities. To better characterize this phenomenon, [...]

  • M. Proietti, D. Lane, G. Lip
    EBioMedicine (2016). Vol. 8

    Abstract
    Chronic kidney disease (CKD) is highly prevalent in atrial fibrillation (AF) patients and associated with an increased risk of adverse outcomes. Our objectives were to study [...]

  • L. Osborne, L. WegenerParfrey
    EBioMedicine (2016). Vol. 8

  • J. Munkley, D. Vodak, K. Livermore, K. James, B. Wilson, B. Knight, P. Mccullagh, J. Mcgrath, M. Crundwell, L. Harries, H. Leung, C. Robson, I. Mills, P. Rajan, D. Elliott
    EBioMedicine (2016).

    Abstract
    Steroid androgen hormones play a key role in the progression and treatment of prostate cancer, with androgen deprivation therapy being the first-line treatment used to control [...]

  • G. Metodieva, S. Adoki, B. Lausen, M. Metodiev
    EBioMedicine (2016). Vol. 8

    Abstract
    SCRIB is a polarity regulator known to be abnormally expressed in cancer at the protein level. Here we report that, in breast cancer, an additional and hidden dimension of [...]

  • T. Mesplède, M. Wainberg
    EBioMedicine (2016). Vol. 8

  • M. Martínez-Hoyos, E. Perez-Herran, G. Gulten, L. Encinas, D. Álvarez-Gómez, E. Alvarez, S. Ferrer-Bazaga, A. García-Pérez, F. Ortega, I. Angulo-Barturen, J. Rullas-Trincado, D. Ruano, P. Torres, P. Castañeda, S. Huss, R. Menéndez, S. Valle, L. Ballell, D. Barros, S. Modha, N. Dhar, F. Signorino-Gelo, J. McKinney, J. García-Bustos, J. Lavandera, J. Sacchettini, M. Jimenez, N. Martín-Casabona, J. Castro-Pichel, A. Mendoza-Losana
    EBioMedicine (2016). Vol. 8

    Abstract
    Despite being one of the first antitubercular agents identified, isoniazid (INH) is still the most prescribed drug for prophylaxis and tuberculosis (TB) treatment and, together [...]

  • A. Lonardo, S. Ballestri, D. Romagnoli, F. Nascimbeni
    EBioMedicine (2016). Vol. 8

  • X. Li, L. Liu, J. Yang, Y. Yu, J. Chai, L. Wang, L. Ma, H. Yin
    EBioMedicine (2016). Vol. 8

    Abstract
    Mesenchymal stem cell (MSC)-derived exosomes have diverse functions in regulating wound healing and inflammation, however, the molecular mechanism of human umbilical cord [...]

  • Y. Liu, B. Wang, W. Zhang, J. Huang, B. Li, M. Zhang, L. Jiang, J. Li, M. Wang, Y. Dai, Z. Zhang, Q. Wang, J. Kong, B. Chen, Y. Zhu, X. Weng, Z. Shen, J. Li, J. Wang, X. Yan, Y. Li, Y. Liang, L. Liu, X. Chen, W. Zhang, J. Yan, J. Hu, S. Shen, J. Chen, L. Gu, D. Pei, Y. Li, G. Wu, X. Zhou, R. Ren, . Cheng, J. Yang, K. Wang, S. Wang, J. Zhang, J. Mi, C. Pui, J. Tang, Z. Chen, S. Chen
    EBioMedicine (2016). Vol. 8

    Abstract
    Genomic landscapes of 92 adult and 111 pediatric patients with B-cell acute lymphoblastic leukemia (B-ALL) were investigated using next-generation sequencing and copy number [...]

  • N. Lin, O. Gonzalez, L. Registre, C. Becerril, B. Etemad, H. Lu, X. Wu, S. Lockman, M. Essex, S. Moyo, D. Kuritzkes, M. Sagar
    EBioMedicine (2016). Vol. 8

    Abstract
    Although both C-C chemokine receptor 5 (CCR5)- and CXC chemokine receptor 4 (CXCR4)-using HIV-1 strains cause AIDS, the emergence of CXCR4-utilizing variants is associated [...]

  • A. Illendula, J. Gilmour, J. Grembecka, V. Tirumala, A. Boulton, A. Kuntimaddi, C. Schmidt, L. Wang, J. Pulikkan, H. Zong, M. Parlak, C. Kuscu, A. Pickin, Y. Zhou, Y. Gao, L. Mishra, M. Adli, L. Castilla, R. Rajewski, K. Janes, M. Guzman, C. Bonifer, J. Bushweller
    EBioMedicine (2016). Vol. 8

    Abstract
    Transcription factors have traditionally been viewed with skepticism as viable drug targets, but they offer the potential for completely novel mechanisms of action that could [...]

  • I. Astsaturov
    EBioMedicine (2016). Vol. 8

  • E. Gazzerro, P. Striano
    EBioMedicine (2016).

  • T. Friedrich, M. Söhn, T. Gutting, K. Janssen, H. Behrens, C. Röcken, M. Ebert, E. Burgermeister
    EBioMedicine (2016). Vol. 8

    Abstract
    Full-length (FL) docking protein-1 (DOK1) is an adapter protein which inhibits growth factor and immune response pathways in normal tissues, but is frequently lost in human [...]

  • D. Grattan
    EBioMedicine (2016). Vol. 8

  • K. Chng, S. Chan, A. Ng, C. Li, A. Jusakul, D. Bertrand, A. Wilm, S. Choo, D. Tan, K. Lim, R. Soetinko, C. Ong, D. Duda, S. Dima, I. Popescu, C. Wongkham, Z. Feng, K. Yeoh, B. Teh, P. Yongvanit, S. Wongkham, V. Bhudhisawasdi, N. Khuntikeo, P. Tan, C. Pairojkul, J. Ngeow, N. Nagarajan
    EBioMedicine (2016). Vol. 8

    Abstract
    Cholangiocarcinoma (CCA) is the primary cancer of the bile duct system. The role of bile duct tissue microbiomes in CCA tumorigenesis is unestablished. To address this, sixty [...]

  • C. Brégnard, J. Guerra, S. Déjardin, F. Passalacqua, M. Benkirane, N. Laguette
    EBioMedicine (2016). Vol. 8

    Abstract
    Fanconi Anemia (FA) is a genetic disorder characterized by elevated cancer susceptibility and pro-inflammatory cytokine production. Using SLX4FANCP deficiency as a working [...]

  • F. Bolduc, A. Lau, C. Rosenfelt, S. Langer, N. Wang, L. Smithson, D. Lefebvre, R. Alexander, C. Dickson, A. Li, A. Becker, P. Subbarao, S. Turvey, J. Pei, M. Sears, P. Mandhane
    EBioMedicine (2016).

    Abstract
    In-utero nutrition is an under-studied aspect of cognitive development. Fruit has been an important dietary constituent for early hominins and humans. Among 808 eligible CHILD-Edmonton [...]

  • M. Berendsen, J. Smits, M. Netea, A. Ven
    EBioMedicine (2016). Vol. 8

    Abstract
    Bacillus Calmette-Guérin (BCG) vaccination possesses effects on health beyond its target disease, the so called “non-specific effects”. We evaluate these effects, as [...]

  • I. Audenhove, J. Gettemans
    EBioMedicine (2016). Vol. 8

    Abstract
    Since their discovery, nanobodies have been used extensively in the fields of research, diagnostics and therapy. These antigen binding fragments, originating from Camelid [...]

  • W. Altarche-Xifro, U. Vicino, M. Muñoz-Martin, A. Bortolozzi, J. Bové, M. Vila, M. Cosma
    EBioMedicine (2016). Vol. 8

    Abstract
    Parkinsons disease is a common neurodegenerative disorder, which is due to the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and for which no definitive [...]

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