Abstract

The results of a study of structural and metabolic changes in CBA mice with hepatocellular carcinoma caused by lithium carbonate nano-sized particles are presented. Light microscopy, electron microscopy and other biochemical methods were used to show that injection of lithium carbonate nano-sized particles to the periphery of the tumour results in enhanced destructive processes within the tumour. The number of neutrophils and macrophages in the tumour increased, whereas the density of blood vessels and haemoglobin concentration were reduced, the extent of tumour necrosis lipid peroxidation and production of nitric oxide was also increased. At the same time, the activity of antioxidant enzymes including superoxide dismutase and catalase remained the same. The introduction of lithium carbonate nano-scaled particles protects vital organs including the heart and lungs from the damaging effect of secondary products of lipid peroxidation.