Abstract

Mammalian topoisomerase 1 (TOP1) is an essential enzyme for normal development. TOP1 relaxes supercoiled DNA to remove helical constraints that can otherwise hinder DNA replication and transcription and thus block cell growth. Unfortunately, this exact activity can covalently trap [...]

Abstract

The relevance of the study is determined by two interrelated points: the need to increase (1) the effectiveness of comprehensive support for persons with ASD and (2) the quality of life of children with ASD and the families in which they grow up. Comprehensive support can be neither [...]