Abstract

Quillaja saponaria bark contains a high percentage of triterpene saponins and has been used for centuries as antiinflammatory and analgesic agent in Chilean folk medicine. In the Present study the anti-inflammatory activities of the aqueous extract of commercially partially purified saponin from Quillaja saponari a Mol. in in vivo animal models. Aqueous extract of the plant material was prepared by cold maceration. The anti-inflammatory activity of a commercial Quillaja saponaria Mol. (QS) saponin extract was investigated by carragenan induced mice paw edema model for acute inflammation (Winter, 1962) [16] . The anti-inflammatory activity was evaluated by carragenan in paw edema model in swiss albino mice (18–20 g). The anti-inflammatory activity was found to be dose dependent in carragenan induced paw edema. QS was found to significantly (p < 0.05) reduce the carragenan induced mice paw edema (38.59%, 20 mg/kg bw) as compared to carragenan control. The percentage inhibition of standard anti-inflammatory drug indomethacin was (55%, 10 mg/kg, bw). The results of the present study demonstrate that the aqueous extract of Quillaja saponaria saponins (QS) possess significant anti-inflammatory activity.

Abstract

This study was designed to evaluate the hepatoprotective activity of aqueous extract and isolated flavone (5-hydroxy, 7, 8, 2’trimethoxy flavone) compound of Andrographis alata against CCl4 induced hepatotoxicity. The hepatotoxicity was induced in albino rats CCl4 (i.p.). Analysis of serum ALT, AST and alkaline phosphatase activities with the concentrations of albumin, total protein and bilirubin was carried out. The activities of all the marker enzymes reported a significant elevation in CCl4 treated rats, which were significantly recovered towards an almost normal level in animals simultaneously administered with aqueous extract and flavone compound. This work suggests that aqueous extract and isolated flavone compound of A. alata exert significant therapeutic effect on CCl4 induced hepatotoxicity in rats.